1491 Reevaluating the dosage of epinephrine required for intraoperative hemostasis in cutaneous surgery

Epinephrine has been co-administered intradermally with an anesthetic for intraoperative hemostasis in dermatology nearly a century at concentration of 1:100,000. Many patients report undesirable side effects such as diaphoresis and tachycardia after repeated injections making it difficult them to tolerate procedures. Currently there is ongoing shortage epinephrine that presented opportunity revisit the being administered cutaneous hemostasis. In our study, concentrations ranging from 1:100,000, 1:500,000, 1:1,000,000 were injected 2% lidocaine right flank pigs. Four replicates each treatment group control analyzed per pig total 3 pigs evaluated this study. Normal saline was negative control. After 7 minutes infiltration, 1cm punch biopsies taken area previously injected. Intraoperative bleeding measured by weighing dry filter paper then applying biopsy site again 4 collection. Our study found both 1:100,000 1:500,000 demonstrated statistically significant reduction compared (p< 0.05) groups 0.05). twice effective normal but roughly half either or Based on results, adequate can be achieved despite using five fold decrease epinephrine. 5-fold lower equally current standard care. This new data suggests not only we reduce healthcare costs less epinephrine, also are more likely these procedures given reduced concentration.